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DZIF Academy 2023

10th Translational DZIF-School

Lübeck, Nov 29 - Dec 01, 2023

Welcome Note

Dear Colleagues and Friends,

It is my pleasure and privilege to invite you to join the 10th Translational DZIF School, which will be held in presence in Lübeck from 29th November to 1st December 2023. With a special focus on translational science we aim to bring together clinical and basic researchers (PhDs, PostDocs and junior group leaders) to discuss latest developments in Infectious Diseases and Clinical Microbiology. In this year´s program major findings from the thematic translational units Malaria and Neglected Tropical Diseases, Gastrointestinal Infections, Hepatitis and Emerging Infections will be presented. In addition, DZIF clinical leave and MD/PhD stipendiaries will present their work in separate sessions to explore their data with established researchers in the field. Furthermore, all other participants will be given the possibility to present their work within the scope of a poster session.

I am looking forward to share with you some exciting days in Lübeck, learning from each other in the dynamic and fastidious field of Infectious Diseases Research.

See you in Lübeck!

Best regards,

Prof. Dr. med. Jan Rupp
Director
Department of Infectious Diseases and Microbiology
University of Lübeck


Prof. Dr. med. Jan Rupp
Download Program Booklet
Download Flyer
12:00 - 14:00
12:00 - 14:00
Registration
14:00 - 14:15
14:00 - 14:15
Welcome Note
Jan Rupp | University of Lübeck
14:15 - 15:15
14:15 - 15:15
Opening Lecture
Chair: Jan Rupp | University of Lübeck
What can we learn from each other? Functional microbiome analysis in the lung
Sébastien Boutin | University of Lübeck
15:15 - 16:15
15:15 - 16:15
Workshop
"Networking at conferences and events"
Moderation: Paul Charlton | German Center for Infection Research, Munich
16:15 - 16:30
16:15 - 16:30
Coffee Break
16:30 - 17:30
16:30 - 17:30
Presentation of DZIF fellowship holders
Chair: Friederike Reinsberg | University Medical Center Hamburg-Eppendorf
16:30
16:30
Clinical and pathogenetic features of acute kidney injury in Lassa fever patients at the Irrua Specialist Teaching Hospital, Edo State, Nigeria
Matin Kohsar | University Medical Center Hamburg-Eppendorf
16:45
16:45
Bacteriophage lysis in Acinetobacter baumannii and the role of it’s capsule
Annika Claßen | University Hospital Cologne
17:00
17:00
Genomic landscape of M. avium complex in Germany
Nils Wetzstein | University Hospital Frankfurt
17:15
17:15
The NLRP3 inflammasome drives the type I IFN-response via the cGAS-STING pathway in Tuberculosis
Claudius Gottschalk | University Hospital Heidelberg
17:30 - 18:30
17:30 - 18:30
TTU Emerging Infections
Chair: Patrick Affeldt | University Hospital Cologne
17:30
17:30
New vaccines against emerging zoonotic infections: From animal models to clinical evaluation
Asisa Volz | University of Veterinary Medicine Hannover
18:00
18:00
Chimeric mouse models to study emerging zoonotic viruses
Beatriz Escudero Pérez | Bernhard Nocht Institute for Tropical Medicine, Hamburg
18:30
18:30
Dinner
08:30 - 09:30
08:30 - 09:30
Presentation of DZIF fellowship holders
Chair: Lukas Macke | Ludwig-Maximilians-Universität Munich
08:30
08:30
Early ART preserves HIV-specific cytotoxicity in follicular CD8 T-cells
Julia Roider | Ludwig-Maximilians-Universität Munich
08:45
08:45
Translation of advanced cell therapies (ACTs) for HIV+ patients into the clinic
Lea Schwarze | University Medical Center Hamburg-Eppendorf
09:00
09:00
Generation of Adeno-associated virus vectors encoding a CRISPR/Cas9 kill switch system to reduce the expression of broadly neutralizing antibodies against HIV-1
Amélie Sophie Belosevic | Heidelberg University
09:15
09:15
Harnessing NK cell effector function against HIV-1-infected microglia for immune control of the brain reservoir
Friederike Reinsberg | University Medical Center Hamburg-Eppendorf
09:30 - 10:30
09:30 - 10:30
TTU Hepatitis
Chair: Johannes Dirks | University Hospital Würzburg
09:30
09:30
Hepatitis D: Shedding light on an overlooked infection
Marc Lütgehetmann | University Medical Center Hamburg-Eppendorf
10:00
10:00
Generation of monoclonal antibodies targeting fiberknob that neutralizes HAdV-5 infection
Britta Möhl-Meinke | Technical University of Munich
10:30 - 11:00
10:30 - 11:00
Coffee Break
11:00 - 12:00
11:00 - 12:00
TTU Gastrointestinal Infections
Chair: Nils Wetzstein | University Hospital Frankfurt
11:00
11:00
TTU Gastrointestinal Infections
Benjamin Heidrich | Hannover Medical School
11:30
11:30
Specific functions of gut microbiota governing infections within the TIPINF study
Marius Vital | Hannover Medical School
12:00 - 13:00
12:00 - 13:00
Lunch
13:00 - 14:00
13:00 - 14:00
Workshop
"Advanced Clinician Scientist in DZIF"
Moderation: Julia Roider | Ludwig-Maximilians-Universität Munich and Benjamin Heidrich | Hannover Medical School
14:00 - 15:00
14:00 - 15:00
Flash Talks
Chair: Nadja Käding | University of Lübeck
1
1
Assessing viral metagenomics for the diagnosis of acute undifferentiated fever in returning travellers: a multicenter cohort studys
Alexandru Tomazatos | Bernhard Nocht Institute for Tropical Medicine, Hamburg
2
2
Discovery of inhibitors of a divergent Plasmodium falciparum protein kinase
Nicolai Koch | Center for Integrative Infectious Disease Research, Heidelberg
3
3
Genetically attenuated blood stage vaccines against malaria
Smilla Steinbrück | Center for Integrative Infectious Disease Research, Heidelberg
4
4
Prevalence study of the microbiome and development of antibiotic resistance in children with Crohn's disease (CD)
Karin Fetter | Institute of Medical Microbiology, Justus Liebig University Giessen
5
5
Differential expression analysis in multi-drug resistant Acinetobacter baumannii; Establishing RNAseq using the MinION platform
Aime Picornell | University Hospital Cologne
6
6
Modulation of antibiotic efficacy by sequential therapy in E. coli causing urinary tract infections
Lisa Göpel | University of Lübeck
7
7
Longitudinal dynamics and characterization of the NK cell repertoire after lung transplantation and correlation to clinical parameters
Nele-Marie Hagen | Hannover Medical School, Transplant Immunology
8
8
The role of cathepsin B in innate antifungal immunity in dendritic cell killing of Histoplasma capsulatum
Charlotte Rohr | University of Lübeck
9
9
Characterization of the HCMV gB-specific B cell and antibody response
Linda Schlachter | University Hospital Cologne
10
10
Relation of enhanced Hepatitis C genome replication to clinical parameters and treatment susceptibility
Tomke Arand | Center for Integrative Infectious Disease Research, Heidelberg
11
11
Establishment and clinical validation of a laboratory developed multiplex PCR assay for absolute quantification of EBV, CMV, VZV, HSV 1, HSV 2 and ?-globin from human tissue samples on a digital PCR system
Lisa Sophie Pflüger | University Medical Center Hamburg-Eppendorf
15:00 - 16:30
15:00 - 16:30
Coffee Break & Poster Session
Poster walk
16:30 - 18:00
16:30 - 18:00
Workshop
"Insights in pharmaceutical industry"
Moderation: Sibyll Escher & Thorsten Reuter & Alexander Baum | MSD Sharp & Dohme GmbH
18:00 - 19:30
18:00 - 19:30
Dinner
19:30
19:30
Networking Event
08:30 - 09:30
08:30 - 09:30
Keynote Lecture
Chair: Jan Rupp | Universität zu Lübeck
Systematic identification of phageome-bacteriome-host cross-talk and its prevention role for precision phageome therapy
Li Deng | Technical University of Munich
09:30 - 10:30
09:30 - 10:30
Presentation of DZIF fellowship holders
Chair: Claudius Gottschalk | University Hospital Heidelberg
09:30
09:30
Characterization of the neutralizing antibody response against BKPyV to identify donors for BKPyV specific memory B-cell isolation
Patrick Affeldt | University Hospital Cologne
09:45
09:45
Microbial colonisation and B cell receptor signaling strength shape the development of the Marginal Zone B cell compartment
Johannes Dirks | University Hospital Würzburg
10:00
10:00
Identification of glycocalyx metabolizing enzymes in members of the biliary microbiota in patients with primary sclerosing cholangitis (PSC)
Benjamin Heidrich | Hannover Medical School
10:15
10:15
HelicoPTER – Regional Prevalence and Antibiotic Resistance of Helicobacter pylori Infection in Germany
Lukas Macke | Ludwig-Maximilians-Universität Munich
10:30 - 11:00
10:30 - 11:00
Coffee Break
11:00 - 12:00
11:00 - 12:00
TTU Malaria and Neglected Tropical Diseases
Chair: Annika Claßen | University Hospital Cologne
11:00
11:00
The research portfolio of the DZIF-TTU Malaria & Neglected Tropical Diseases
Michael Ramharter | Bernhard Nocht Institute for Tropical Medicine, Hamburg
11:30
11:30
Multi-Disease Combination Regimens for Mass Drug Administration
Johannes Mischlinger | Bernhard Nocht Institute for Tropical Medicine, Hamburg
12:00 - 12:30
12:00 - 12:30
Presentation of DZIF fellowship holders
Chair: Matin Kohsar | University Medical Center Hamburg-Eppendorf
12:00
12:00
Polyfunctional hepatitis D virus-specific CD4+ T-cell responses are detectable during low viremia time-points in patients chronically infected with the hepatitis D virus
Helenie Kefalakes | Hannover Medical School
12:15
12:15
Development of a live-attenuated monkeypox virus for use in improved diagnostics
Vincent Klatt | Leibniz Instiute of Virology, Hamburg
12:30 - 12:45
12:30 - 12:45
Closing Remarks
Jan Rupp | University of Lübeck
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